[Association of vitamin D receptor gene polymorphisms with susceptibility to bone and joint tuberculosis in Chinese Han population].

Abstract

OBJECTIVE:

To investigate the association between vitamin D receptor (VDR) gene Apa I polymorphism and the susceptibility to bone and joint tuberculosis in Chinese Han population.

METHODS:

Between May, 2015 and June, 2016, 100 patients with bone and joint tuberculosis and 100 healthy volunteers were recruited concomitantly in Heyuan Hospital of Traditional Chinese Medicine. Vitamin D receptor gene Apa I polymorphisms in these subjects were analyzed using SNaPshot.

RESULT:

The genotype frequencies of Apa I-AA, Apa I-Aa and Apa I-aa were 51%, 41%, and 8% in the case group and 33%, 55%, and 12% in the control group, respectively, showing significant differences between the two groups (P<0.05). The genotype of Apa I-AA was significantly higher in the case group with an odds ratio (OR) of 2.073 (95% CI: 1.142-3.763).

CONCLUSION:

The Apa I polymorphisms of the VDR gene are associated with the susceptibility to bone and joint tuberculosis in Chinese Han population, and individuals with a Apa I-AA genotype are at greater risks to develop bone and joint tuberculosis.

• Authors: Jia-Wei Zhang, Qiang Zhang, Dong-Bin Qu, Zhen Lin, Xue-Ming Ma, Xin Zhong, Chao-Hui Sang, Xu-Shi Chen, Zu-Kun Song, Piao Huang, Jian-Ming Jiang
• Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University (Nan Fang Yi Ke Da Xue Xue Bao) Vol. 37 Issue 5 Pg. 704-706 (05 20 2017) ISSN: 1673-4254 [Print] China
• PMID: 28539299 (Publication Type: Journal Article)

Chemical References

• Receptors, Calcitriol

Topics

• Asian People (genetics)
• Case-Control Studies
• China
• Gene Frequency
• Genetic Predisposition to Disease
• Genotype
• Humans
• Polymorphism, Genetic
• Receptors, Calcitriol (genetics)
• Tuberculosis, Osteoarticular (genetics)