5-HT3 Receptors: A Potential Therapeutic Target for Epilepsy.

Abstract

BACKGROUND:

Epilepsy is a syndrome of brain dysfunction caused by spontaneous, abnormal discharge. Many anti-epileptic drugs have developed in past decades. 5-HT is an important neurotransmitter in the central and peripheral nervous system of the human body which is involved in a number of physiological activities, such as sensation, movement, and behavior. 5-HT subtype have been divided into seven sub-groups from 5-HT1 to 5HT7. However, the role of 5-HT3 receptor on epilepsy is unclear. Therefore, in this article, the possible role of 5-HT3 receptor on epilepsy was systemically reviewed.

METHODS:

Data were collected from Web of Science, Medline, Pubmed, Scopus, through searching of these keywords: "5-HT3" and "epilepsy".

RESULTS:

An increasing number of studies have shown that the activation of the 5-HT3 receptor can inhibit epileptic seizures, while inhibition of the 5-HT3 receptor can promote spike waves.

CONCLUSION:

In this review, we discuss the relationship between the 5HT3 receptor and epilepsy; this review may provide a new insight for clinical application of epilepsy treatment.

• Authors: Hongyan Zhao, Yang Lin, Shurui Chen, Xin Li, Hongliang Huo
• Journal: Current neuropharmacology (Curr Neuropharmacol) Vol. 16 Issue 1 Pg. 29-36 ( 2018) ISSN: 1875-6190 [Electronic] United Arab Emirates
• PMID: 28486926 (Publication Type: Journal Article, Review)
• Copyright: Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

Chemical References

• Receptors, Serotonin, 5-HT3
• Serotonin Agents

Topics

• Animals
• Brain (drug effects, metabolism)
• Databases, Factual (statistics & numerical data)
• Epilepsy (drug therapy, genetics, metabolism)
• Humans
• Receptors, Serotonin, 5-HT3 (genetics, metabolism)
• Serotonin Agents (pharmacology, therapeutic use)