Optimization of the Synthesis of Flavone-Amino Acid and Flavone-Dipeptide Hybrids via Buchwald-Hartwig Reaction.

Abstract	The article describes the development of Buchwald-Hartwig amination of different bromoflavones with amino acid and peptide derivatives as nitrogen source giving unique structures. The previously observed racemization, which occurred during the synthesis of flavone-amino acid hybrids, was successfully prevented in most cases. The biological assays of these novel structures showed cytotoxic effects on different cancer cell lines.
Authors	Dávid Pajtás, Krisztina Kónya, Attila Kiss-Szikszai, Petr Džubák, Zoltán Pethő, Zoltán Varga, György Panyi, Tamás Patonay
Journal	The Journal of organic chemistry (J Org Chem) Vol. 82 Issue 9 Pg. 4578-4587 (May 05 2017) ISSN: 1520-6904 [Electronic] United States
PMID	28441016 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Amino Acids Dipeptides Flavones
Topics	Amino Acids (chemistry) Cell Line, Tumor Dipeptides (chemistry) Drug Screening Assays, Antitumor Flavones (chemistry) Humans Kinetics Microbial Sensitivity Tests Spectrum Analysis (methods)

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