Release of Doxorubicin by a Folate-Grafted, Chitosan-Coated Magnetic Nanoparticle.

Abstract

In clinical tumor therapy, chemotherapeutic routes have caused severe side effects; current delivery methods are unsatisfactory. Successful design of a remotely folate (FA)-grafted chitosan (CS)-coated magnetic nanoparticle (MNP) with low toxicity, has been achieved. A chemotherapeutic drug such as doxorubicin (DOX), is loaded in the MNP-based matrix (FA-grafted CS-DOX-TPP-MNP), which is coated by an activated target tumor molecule of FA-grafted CS biopolymer with the inclusion of tripolyphosphate (TPP) as a linker. The resultant nano-complexes exhibited random aggregates (~240 nm) and zeta potential (-24.9 mV). In vivo experiments using athymic BALB/c nude mice with human glioblastoma U87 cells in a subcutaneous tumor model revealed that magnetic guidance of FA-grafted CS-DOX-TPP-MNP, injected via the tail vein, significantly decreased tumor growth. This manuscript demonstrates the feasibility of magnetizing control of FA-grafted CS-DOX-TPP-MNP to enhance the localization of drug release.

• Authors: Chung-Lin Yang, Jyh-Ping Chen, Kuo-Chen Wei, Ju-Yu Chen, Chia-Wen Huang, Zi-Xian Liao
• Journal: Nanomaterials (Basel, Switzerland) (Nanomaterials (Basel)) Vol. 7 Issue 4 (Apr 13 2017) ISSN: 2079-4991 [Print] Switzerland
• PMID: 28406429 (Publication Type: Journal Article)