Similar Immunological Profiles Between Nonprogressing HIV Infection in Children and Nonpathogenic SIV Infection.

Abstract

In the absence of antirretroviral therapy (ART), HIV infection leads to progression to AIDS in most infected individuals. However, there is a small group of HIV-infected patients capable of spontaneously controlling HIV infection, known as the elite controllers (less than 1% of total infected population). These patients maintain undetectable levels of HIV replication, in part, due to a continuously effective HIV specific T cell response. Moreover, in HIV-infected patients with suppressed viremia under ART, a chronic activation of the immune system persist, which can be related to a poor clinical outcome including death, development of co-morbidities, AIDS and non-AIDS defining events. Indeed, several studies highlight that a high level of immune activation rather than HIV replication is the major contributing factor to progression during HIV infection.

• Authors: Eva Poveda, Enrique Martin-Gayo
• Journal: AIDS reviews (AIDS Rev) 2017 Jan-Mar Vol. 19 Issue 1 Pg. 54-55 ISSN: 1698-6997 [Electronic] Spain
• PMID: 28182614 (Publication Type: Journal Article)

Chemical References

• Anti-HIV Agents

Topics

• Animals
• Anti-HIV Agents (therapeutic use)
• CD4 Lymphocyte Count
• Child
• HIV Infections (immunology)
• Humans
• Simian Acquired Immunodeficiency Syndrome (immunology)