HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Patching retinal breaks with Seprafilm for treating retinal detachments in humans: 9 years of follow-up.

Abstract
PurposeTo describe the long-term surgical outcomes of four patients treated for retinal detachment using Seprafilm as a novel technique.MethodsRetinal breaks in four eyes were covered with Seprafilm using a transvitreal approach after cataract surgery, pars plana vitrectomy, fluid-air exchange, and laser photocoagulation. Neither long-standing gas nor silicone oil was used. The patients were not instructed to maintain a specific head positioning postoperatively.ResultsSuccessful retinal reattachment was achieved with a single surgery in all four eyes, and none developed proliferative vitreoretinopathy. The mean best-corrected visual acuity preoperatively and 9 years postoperatively were 20/97 and 20/33, respectively. The intraocular pressure increased several days postoperatively that lasted no longer than 2 weeks. Visual field defects either in the inferonasal or inferotemporal quadrant were detected postoperatively. The mean electroretinogram a- and b-wave amplitude ratios of the operated eyes to the fellow eyes were 0.68 and 0.64 preoperatively and 0.87 and 0.92 postoperatively, respectively. The mean corneal endothelial cell density was 2365 cells/mm2 preoperatively and 2592 cells/mm2 postoperatively.ConclusionCovering retinal breaks with Seprafilm may promote retinal reattachment without gas tamponade and postoperative head positioning. The visual outcomes 9 years postoperatively showed no apparent adverse effects of intraocular application of Seprafilm.
AuthorsM Haruta, M Arai, J Sueda, T Hirose, R Yamakawa
JournalEye (London, England) (Eye (Lond)) Vol. 31 Issue 5 Pg. 776-780 (May 2017) ISSN: 1476-5454 [Electronic] England
PMID28128794 (Publication Type: Journal Article)
Chemical References
  • Membranes, Artificial
  • Seprafilm
  • Hyaluronic Acid
Topics
  • Adult
  • Aged
  • Electroretinography
  • Female
  • Follow-Up Studies
  • Humans
  • Hyaluronic Acid (pharmacology)
  • Male
  • Membranes, Artificial
  • Middle Aged
  • Prospective Studies
  • Retinal Perforations (diagnosis, therapy)
  • Sensory Deprivation
  • Time Factors
  • Treatment Outcome
  • Visual Acuity
  • Vitrectomy

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: