Serological diagnosis of mumps: Value of the titration of specific IgG.

Abstract

INTRODUCTION:

The aim of this study was to evaluate a cut-off point of the titration of IgG by ELISA in the diagnosis of mumps.

METHODS:

A study was made of serum samples from 85 mumps cases (confirmed by PCR in saliva) and 2,351 controls of the general population of the Region of Madrid.

RESULTS:

The IgM detection was positive in 21 cases (sensitivity of 24.7%). The best cut-off point corresponded to IgG titres ≥4,900 (sensitivity of 64.7% and specificity of 86.1%). Among 42 patients immunised with at least one dose of measles mumps, rubella vaccine IgM was detected in 4 cases. However, the detection of IgG ≥4,900 was positive in 29 (sensitivity of 69.0%).

CONCLUSIONS:

An IgG result of ≥4.900 was almost 5 times more probable in a patient with mumps than in a non-infected patient. The detection of high titres of IgG against mumps could improve the IgM results in vaccinated people.

• Authors: Juan Carlos Sanz, Belén Ramos, Aurora Fernández, Luis García-Comas, Juan Emilio Echevarría, Fernando de Ory
• Journal: Enfermedades infecciosas y microbiologia clinica (English ed.) (Enferm Infecc Microbiol Clin (Engl Ed)) Vol. 36 Issue 3 Pg. 172-174 (Mar 2018) ISSN: 2529-993X [Electronic] Spain
• Vernacular Title: Diagnóstico serológico de parotiditis epidémica: valor de la titulación de IgG específica.
• PMID: 28126326 (Publication Type: Journal Article)
• Copyright: Copyright © 2016 Elsevier España, S.L.U. and Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.

Chemical References

• Immunoglobulin G

Topics

• Adolescent
• Adult
• Child
• Child, Preschool
• Enzyme-Linked Immunosorbent Assay
• Female
• Humans
• Immunoglobulin G (blood)
• Male
• Middle Aged
• Mumps (blood, diagnosis)
• Serologic Tests
• Young Adult