Functional effector memory T cells contribute to protection from superinfection with heterologous simian immunodeficiency virus or simian-human immunodeficiency virus isolates in Chinese rhesus macaques.

Abstract

Many studies have revealed a protective effect of infection of an individual with an immunodeficiency virus against subsequent infection with a heterologous strain. However, the extent of protection against superinfection conferred by the first infection and the biological consequences of superinfection are not well understood. Here, we report that a rhesus monkey model of mucosal superinfection was established to investigate the protective immune response. Protection against superinfection was shown to correlate with the extent of the polyfunctionality of CD4+ effector memory T cells, whereas neutralizing antibody responses did not protect against superinfection in this model. Notably, immunodeficiency-virus-associated effector memory T-cell responses might significantly contribute to the suppression of virus superinfection. This provides a potential theoretical basis for the development of an HIV/AIDS vaccine.

• Authors: Ming Sun, Huiwen Zheng, Yingpeng Xie, Bingxiang Li, Haiting Long, Ge Guo, Lei Guo, Jingjing Wang, Ruotong Ning, Yue Li, Longding Liu
• Journal: Archives of virology (Arch Virol) Vol. 162 Issue 5 Pg. 1211-1221 (May 2017) ISSN: 1432-8798 [Electronic] Austria
• PMID: 28110425 (Publication Type: Journal Article)

Chemical References

• Antibodies, Neutralizing
• Antibodies, Viral

Topics

• Animals
• Antibodies, Neutralizing (blood, immunology)
• Antibodies, Viral (blood, immunology)
• CD4-Positive T-Lymphocytes (immunology)
• CD8-Positive T-Lymphocytes (immunology)
• Disease Models, Animal
• Female
• Immunologic Memory (immunology)
• Macaca mulatta
• Male
• Simian Acquired Immunodeficiency Syndrome (pathology, virology)
• Simian Immunodeficiency Virus (immunology, isolation & purification)
• Superinfection (immunology, prevention & control, virology)
• Viral Load