Sleep-disordered breathing is associated with higher carboxymethyllysine level in elderly women but not elderly men in the cardiovascular health study.

Abstract

CONTEXT:

Carboxymethyl-lysine (CML) results from oxidative stress and has been linked to cardiovascular disease.

OBJECTIVE:

The objective of this study is to investigate the association between sleep-disordered breathing (SDB) - a source of oxidative stress - and CML.

MATERIALS AND METHODS:

About 1002 participants in the Cardiovascular Health Study (CHS) were studied.

RESULTS:

Women with SDB had significantly higher CML concentration compared with those without SDB (OR = 1.63, 95%CI = 1.03-2.58, p = 0.04). The association was not significant among men.

DISCUSSION:

SDB was associated with CML concentration among elderly women but not men in the Cardiovascular Health Study.

CONCLUSION:

Accumulation of CML may be an adverse health consequence of SDB.

• Authors: Peter D Ahiawodzi, Richard A Kerber, Kira C Taylor, Frank D Groves, Elizabeth O'Brien, Joachim H Ix, Jorge R Kizer, Luc Djoussé, Russell P Tracy, Anne B Newman, David S Siscovick, John Robbins, Kenneth Mukamal
• Journal: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals (Biomarkers) 2017 May - Jun Vol. 22 Issue 3-4 Pg. 361-366 ISSN: 1366-5804 [Electronic] England
• PMID: 28055285 (Publication Type: Journal Article)

Chemical References

• N(6)-carboxymethyllysine
• Lysine

Topics

• Aged
• Aged, 80 and over
• Cardiovascular Diseases (blood)
• Case-Control Studies
• Female
• Humans
• Lysine (analogs & derivatives, blood)
• Male
• Oxidative Stress
• Sex Factors
• Sleep Apnea Syndromes (blood)