Serum ghrelin levels in patients with Behcet's disease.

Abstract

INTRODUCTION:

Behcet's disease (BD) is a chronic, relapsing, systemic vasculitis of unknown etiology.

AIM:

To measure serum ghrelin levels in BD patients and healthy controls and to investigate its association with metabolic syndrome (MetS).

MATERIAL AND METHODS:

Thirty BD patients and 30 healthy individuals were enrolled in the study. Ghrelin levels were measured in blood samples using ELISA.

RESULTS:

The mean serum ghrelin level in BD patients (28.57 ±14.04) was significantly lower compared to healthy controls (40.72 ±23.21) (p = 0.01). The mean serum ghrelin level in BD patients who had MetS (24.18 ±12.73) was lower compared to BD patients who did not have MetS (30.77 ±14.45), but this difference was not significant (p > 0.05).

CONCLUSIONS:

Ghrelin levels were lower in BD patients compared to healthy controls. There was no association between reduced ghrelin levels and MetS; however, there was a negative correlation between ghrelin levels and disease activity.

• Authors: Ilker Erden, Haydar Uçak, Betül Demir, Demet Cicek, Selma Bakar Dertlioğlu, Suleyman Aydin, Savas Ozturk
• Journal: Postepy dermatologii i alergologii (Postepy Dermatol Alergol) Vol. 33 Issue 6 Pg. 450-456 (Dec 2016) ISSN: 1642-395X [Print] Poland
• PMID: 28035223 (Publication Type: Journal Article)