An optimal Wilcoxon-Mann-Whitney test of mortality and a continuous outcome.

Abstract

We consider a two-group randomized clinical trial, where mortality affects the assessment of a follow-up continuous outcome. Using the worst-rank composite endpoint, we develop a weighted Wilcoxon-Mann-Whitney test statistic to analyze the data. We determine the optimal weights for the Wilcoxon-Mann-Whitney test statistic that maximize its power. We derive a formula for its power and demonstrate its accuracy in simulations. Finally, we apply the method to data from an acute ischemic stroke clinical trial of normobaric oxygen therapy.

• Authors: Roland A Matsouaka, Aneesh B Singhal, Rebecca A Betensky
• Journal: Statistical methods in medical research (Stat Methods Med Res) Vol. 27 Issue 8 Pg. 2384-2400 (08 2018) ISSN: 1477-0334 [Electronic] England
• PMID: 27920364 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Topics

• Brain Ischemia (mortality, therapy)
• Humans
• Mortality
• Oxygen Inhalation Therapy
• Randomized Controlled Trials as Topic
• Statistics, Nonparametric
• Stroke (mortality, therapy)