Abstract |
Bacteriophages (phages) are known to effectively kill extracellular multiplying bacteria. The present study demonstrated that phages penetrated bovine mammary epithelial cells and cleared intracellular Staphylococcus aureus in a time-dependent manner. In particular, phage vB_SauM_JS25 reached the nucleus within 3 h postincubation. The phages had an endocytotic efficiency of 12%. This ability to kill intracellular host bacteria suggests the utility of phage-based therapies and may protect patients from recurrent infection and treatment failure.
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Authors | Lili Zhang, Lichang Sun, Ruicheng Wei, Qiang Gao, Tao He, Cunfa Xu, Xianjin Liu, Ran Wang |
Journal | Antimicrobial agents and chemotherapy
(Antimicrob Agents Chemother)
Vol. 61
Issue 2
(02 2017)
ISSN: 1098-6596 [Electronic] United States |
PMID | 27919889
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2017 American Society for Microbiology. |
Topics |
- Animals
- Bacteriophages
(physiology)
- Cattle
- Cell Line
- Cell Nucleus
(microbiology, virology)
- Epithelial Cells
(microbiology, virology)
- Mammary Glands, Animal
(cytology)
- Microscopy, Confocal
- Staphylococcus aureus
(physiology)
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