Potent Inducers of Endogenous Antimicrobial Peptides for Host Directed Therapy of Infections.

Abstract

A new concept for treatment of infections is induction of our own antimicrobial peptides and the presented novel class of inducer, aroylated phenylenediamines (APDs), gives up to 20 to 30-fold induction of the human antimicrobial peptide LL-37, in vitro. In addition, oral administration of an APD in a rabbit model of Shigellosis resulted in recovery from the infection in a few days implying that APD's are promising candidates for treatment of infections.

• Authors: H Ottosson, F Nylén, P Sarker, E Miraglia, P Bergman, G H Gudmundsson, R Raqib, B Agerberth, R Strömberg
• Journal: Scientific reports (Sci Rep) Vol. 6 Pg. 36692 (11 09 2016) ISSN: 2045-2322 [Electronic] England
• PMID: 27827460 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antimicrobial Cationic Peptides
• Phenylenediamines
• Cathelicidins

Topics

• Administration, Oral
• Animals
• Antimicrobial Cationic Peptides (metabolism)
• Cell Line
• Dysentery, Bacillary (drug therapy)
• Female
• Humans
• Male
• Phenylenediamines (chemical synthesis, chemistry, pharmacology)
• Rabbits
• Cathelicidins