Toxicity and efficacy of CdO nanostructures on the MDCK and Caki-2 cells.
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| Abstract |
This article reports the toxicological effects of synthesized cadmium oxide (CdO) nanostructures via a simple green route using a Polygala tenuifolia root extract on normal and renal tumor cells. First, the formation of cadmium oxide nanostructures were confirmed structurally by Fourier transform infrared spectroscopy, X-ray diffraction, and X-ray photoelectron spectroscopy (XPS). The powder was crystallized in a cubic structure with a space group of Fm-3m. The mean crystallize size was approximately 40 and 44nm from the Scherrer and size-strain plots, respectively. The surface states of the cadmium oxide nanostructure using the O 1s and Cd 3d spectra were analyzed by XPS. Transmission electron microscopy showed that the simple green route resulted in various morphologies of synthesized cadmium oxide, such as trigonal-, tetrahedron-, and sheet-like structures. Finally, the toxic effects of the cadmium oxide nanostructures on Madin-Darby canine kidney epithelial cells (MDCK cells), as well as the human renal cancer cell line (Caki-2 cells) were investigated using a SRB assay and two-color flow cytometry analysis. The cadmium oxide nanostructures showed significant cell growth inhibition in normal and also tumor cells in a dose-dependent manner. On the other hand, the inhibition was higher in the cancer cells compared to the normal cells.
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| Authors | T V M Sreekanth, Muthuraman Pandurangan, G R Dillip, Doo Hwan Kim, Yong Rok Lee |
| Journal | Journal of photochemistry and photobiology. B, Biology (J Photochem Photobiol B) Vol. 164 Pg. 174-181 (Nov 2016) ISSN: 1873-2682 [Electronic] Switzerland |
| PMID | 27689742 (Publication Type: Journal Article) |
| Copyright | Copyright © 2016 Elsevier B.V. All rights reserved. |
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