Linear trichilemmomas on the ankle of a 28-year-old female.

Abstract

Trichilemmomas are benign cutaneous proliferations derived from the outer root sheath of the hair follicle. They most often occur on the head and neck region and show a female predominance. When multiple, they are associated with Cowden syndrome (CS), a rare disorder due to an autosomal dominant germline mutation in PTEN (phosphatase and tensin homolog on chromosome 10), a tumor suppressor gene. Trichilemmomas outside of the head and neck region are rare, and as such, the association with CS is not clear. A 28-year-old healthy female with no significant family history of cancer presented to her dermatologist with multiple erythematous papules on the left anterior ankle, starting at birth. A shave biopsy confirmed the diagnosis of trichilemmoma with focal desmoplastic features (or desmoplastic trichilemmoma). A PTEN immunohistochemical study showed patchy (but not complete) loss of staining of the lesional cells. After shave removal, the trichilemmomas recurred 1-2 months later.

• Authors: Jessica L Gonzalez, Natalia Plotnikova, Andrew Seymour, Ciaran M Mannion, Richard Danialan, David Rosmarin
• Journal: Journal of cutaneous pathology (J Cutan Pathol) Vol. 44 Issue 1 Pg. 93-97 (Jan 2017) ISSN: 1600-0560 [Electronic] United States
• PMID: 27683091 (Publication Type: Case Reports)
• Copyright: © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• PTEN Phosphohydrolase
• PTEN protein, human

Topics

• Adult
• Ankle
• Female
• Hair Diseases (pathology)
• Hair Follicle (pathology)
• Hamartoma (genetics, pathology)
• Humans
• PTEN Phosphohydrolase (analysis, biosynthesis)
• Skin Diseases (genetics, pathology)