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A Case of Lung Adenocarcinoma Resistant to Crizotinib Harboring a Novel EML4-ALK Variant, Exon 6 of EML4 Fused to Exon 18 of ALK.

AuthorsSatoshi Anai, Masafumi Takeshita, Nobuhisa Ando, Yuuki Ikematsu, Shohei Mishima, Koichi Ishida, Kouji Inoue
JournalJournal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer (J Thorac Oncol) Vol. 11 Issue 10 Pg. e126-8 (10 2016) ISSN: 1556-1380 [Electronic] United States
PMID27663401 (Publication Type: Case Reports, Letter)
Chemical References
  • EML4-ALK fusion protein, human
  • Oncogene Proteins, Fusion
  • Protein Kinase Inhibitors
  • Pyrazoles
  • Pyridines
  • Crizotinib
Topics
  • Adenocarcinoma (drug therapy, genetics, pathology)
  • Crizotinib
  • Drug Resistance, Neoplasm (genetics)
  • Exons
  • Gene Rearrangement
  • Genetic Variation
  • Humans
  • Lung Neoplasms (drug therapy, genetics, pathology)
  • Male
  • Middle Aged
  • Oncogene Proteins, Fusion (genetics)
  • Protein Kinase Inhibitors (pharmacology)
  • Pyrazoles (pharmacology)
  • Pyridines (pharmacology)

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