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Mutating heme oxygenase-1 into a peroxidase causes a defect in bilirubin synthesis associated with microcytic anemia and severe hyperinflammation.

AuthorsJohann Greil, Maria V Verga-Falzacappa, Nicole E Echner, Wolfgang Behnisch, Obul R Bandapalli, Paulina Pechanska, Stephan Immenschuh, Vijith Vijayan, Jozsef Balla, Hirokatsu Tsukahara, Marion Schneider, Gritta Janka, Maren Claus, Thomas Longerich, Martina U Muckenthaler, Andreas E Kulozik
JournalHaematologica (Haematologica) Vol. 101 Issue 11 Pg. e436-e439 (11 2016) ISSN: 1592-8721 [Electronic] Italy
PMID27662012 (Publication Type: Case Reports, Letter, Research Support, Non-U.S. Gov't)
Chemical References
  • Peroxidase
  • Heme Oxygenase-1
  • Bilirubin
Topics
  • Anemia, Iron-Deficiency (etiology)
  • Bilirubin (biosynthesis)
  • Heme Oxygenase-1 (genetics)
  • Humans
  • Infant
  • Inflammation (etiology)
  • Macrophages (immunology)
  • Male
  • Oxidative Stress
  • Peroxidase (genetics)

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