Abstract | OBJECTIVE: METHOD: The present research was a cross-sectional study in which 19 patients with major depressive disorder and 19 age- and sex-matched healthy comparison subjects underwent positron emission tomography scanning to evaluate the norepinephrine transporter availability measured by the radioligand (S,S)-[18F]FMeNER-D2. Norepinephrine transporter availability in the thalamus and its subregions was quantified in terms of nondisplaceable binding potential (BPND). The authors also analyzed the association between norepinephrine transporter availability and clinical symptoms. RESULTS: Compared with healthy subjects, patients with major depressive disorder showed 29.0% higher BPND values in the thalamus and, in particular, 28.2% higher values in the thalamic subregion anatomically connected to the prefrontal cortex. Elevated norepinephrine transporter availability in the thalamus in patients was positively correlated with attention, as measured by the Trail Making Test, part A. CONCLUSIONS:
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Authors | Sho Moriguchi, Makiko Yamada, Harumasa Takano, Tomohisa Nagashima, Keisuke Takahata, Keita Yokokawa, Takehito Ito, Tatsuya Ishii, Yasuyuki Kimura, Ming-Rong Zhang, Masaru Mimura, Tetsuya Suhara |
Journal | The American journal of psychiatry
(Am J Psychiatry)
Vol. 174
Issue 1
Pg. 36-41
(Jan 01 2017)
ISSN: 1535-7228 [Electronic] United States |
PMID | 27631962
(Publication Type: Journal Article)
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Chemical References |
- 2-(alpha-(2-fluoromethoxyphenoxy)benzyl)morpholine
- Morpholines
- Norepinephrine Plasma Membrane Transport Proteins
- SLC6A2 protein, human
- Norepinephrine
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Topics |
- Adult
- Brain Mapping
- Cross-Sectional Studies
- Depressive Disorder, Major
(diagnosis, physiopathology, psychology)
- Female
- Humans
- Imaging, Three-Dimensional
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Morpholines
- Multimodal Imaging
- Nerve Net
(diagnostic imaging, physiopathology)
- Norepinephrine
(physiology)
- Norepinephrine Plasma Membrane Transport Proteins
(physiology)
- Positron-Emission Tomography
- Prefrontal Cortex
(diagnostic imaging, physiopathology)
- Synaptic Transmission
(physiology)
- Thalamus
(diagnostic imaging, physiopathology)
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