Short-term effects of intravitreal dexamethasone implant (OZURDEX®) on choroidal thickness in patients with naive branch retinal vein occlusion.

Abstract

PURPOSE:

The objective of this study was to evaluate subfoveal choroidal thickness (SFCT) using enhanced depth imaging optical coherence tomography (EDI-OCT) in patients with naïve branch retinal vein occlusion (BRVO) before and after intravitreal dexamethasone implant (Ozurdex®) injection.

METHODS:

Thirty-nine patients with unilateral BRVO and 35 healthy subjects were included in this prospective study. Choroidal thickness was evaluated by EDI-OCT at baseline and 1 month after dexamethasone implant.

RESULTS:

The mean SFCT measured in 39 patients with BRVO was 299.41 ± 55.86 µm, significantly greater than that in contralateral eyes (283.76 ± 57.44 µm; p=0.009) and control eyes (276.14 ± 39.06 µm; p=0.044). The mean SFCT after the treatment was 279.64 ± 50.96 µm, significantly thinner than that before intravitreal dexamethasone therapy (p=0.004).

CONCLUSIONS:

SFCT in treatment-naive BRVO eyes was significantly greater than that in contralateral eyes and healthy eyes and decreased significantly after intravitreal dexamethasone implantation.

• Authors: Hasan Basri Arifoglu, Necati Duru, Orhan Altunel, Burhan Baskan, Bedirhan Alabay, Mustafa Atas
• Journal: Arquivos brasileiros de oftalmologia (Arq Bras Oftalmol) 2016 Jul-Aug Vol. 79 Issue 4 Pg. 243-6 ISSN: 1678-2925 [Electronic] Brazil
• PMID: 27626149 (Publication Type: Journal Article)

Chemical References

• Glucocorticoids
• Dexamethasone

Topics

• Adult
• Aged
• Aged, 80 and over
• Case-Control Studies
• Choroid (diagnostic imaging, drug effects)
• Dexamethasone (administration & dosage)
• Female
• Glucocorticoids (administration & dosage)
• Humans
• Intraocular Pressure
• Intravitreal Injections
• Macular Edema (prevention & control)
• Male
• Middle Aged
• Prospective Studies
• Reference Values
• Retinal Vein Occlusion (diagnostic imaging, drug therapy)
• Statistics, Nonparametric
• Time Factors
• Tomography, Optical Coherence (methods)
• Treatment Outcome
• Visual Acuity