The Prognostic Value of D-Dimer in De Novo Acute Myeloid Leukemia.

Abstract

BACKGROUND:

The aim of this study was to evaluate the prognostic value of D-dimer in patients with newly diagnosed de novo non-M3 subtypes of acute myeloid leukemia (AML).

MATERIALS AND METHODS:

We retrospectively analyzed the clinical data from 245 patients with newly diagnosed de novo non-M3 subtypes of AML at the Tongji Hospital from January 2010 to December 2014.

RESULTS:

The comparison results indicated that the D-dimer values were higher in patients with AML with the following characteristics: WBC count ≥ 20 × 10(9)/L (2.20 versus 6.00, P = 0.001), percentage of bone marrow (BM) blasts ≥ 60% (2.06 versus 5.69, P = 0.003), and poor-risk stratification (P < 0.001). Cox univariate regression analysis showed that overall survival was negatively affected by the following factors: age > 60 years, poor-risk stratification, BM blast cell count ≥60%, and D-dimer ≥1μg/mL. Multivariate analysis showed that only age > 60 years (P < 0.001), BM blast cell counts ≥60% (P = 0.001) and D-dimer values ≥1μg/mL (P = 0.014) were independent adverse prognostic factors.

CONCLUSIONS:

D-dimer ≥1μg/mL is related to high tumor burden and can be considered as an independent prognostic factor in patients with de novo non-M3 AML.

• Authors: Yudi Geng, Cui Jian, Shijia Yang, Sijing Wu, Jianfeng Zhou, Dengju Li
• Journal: The American journal of the medical sciences (Am J Med Sci) Vol. 352 Issue 2 Pg. 129-33 (08 2016) ISSN: 1538-2990 [Electronic] United States
• PMID: 27524209 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2016 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers
• Fibrin Fibrinogen Degradation Products
• fibrin fragment D

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Biomarkers (blood)
• Female
• Fibrin Fibrinogen Degradation Products (metabolism)
• Follow-Up Studies
• Hospitalization (trends)
• Humans
• Leukemia, Myeloid, Acute (blood, diagnosis, mortality)
• Male
• Middle Aged
• Prognosis
• Retrospective Studies
• Survival Rate (trends)
• Young Adult