Fluoroquinolone resistance of Streptococcus pneumoniae isolates causing invasive disease: special focus on zabofloxacin.

Abstract

The present study examined the in vitro activity of various antibiotics including zabofloxacin, against isolates responsible for invasive pneumococcal diseases. Between 1997 and 2008, a total of 208 isolates were collected from sterile fluids, including blood (n=196, 94.2%), pleural fluid (n=5, 2.4%), cerebrospinal fluid (n=5, 2.4%), and ascites (n=2, 1.0%). Zabofloxacin showed the lowest MIC50 (0.015μg/mL) and MIC90 (0.025μg/mL) values of all the tested antibiotics. Rates of isolates resistant to penicillin (MIC ≥8μg/mL), ceftriaxone (MIC ≥4μg/mL) and levofloxacin (MIC ≥8μg/mL) were 3.4%, 0.4% and 2.0%, respectively. Four isolates (2.0%) were resistant to levofloxacin, and zabofloxacin showed low MICs (range, 0.025-0.125μg/mL). Zabofloxacin shows potent in vitro activity against S. pneumoniae isolates that caused invasive disease, even strains that are resistant to levofloxacin.

• Authors: Tark Kim, Su-Jin Park, Yong Pil Chong, Ki-Ho Park, Yu-Mi Lee, Hyo-Lim Hong, Hee Seung Kim, Eun Sil Kim, Sungkyoung Lee, Dong Rack Choi, Sung-Han Kim, Jin-Yong Jeong, Sang-Oh Lee, Sang-Ho Choi, Jun Hee Woo, Yang Soo Kim
• Journal: Diagnostic microbiology and infectious disease (Diagn Microbiol Infect Dis) Vol. 86 Issue 2 Pg. 181-3 (Oct 2016) ISSN: 1879-0070 [Electronic] United States
• PMID: 27498611 (Publication Type: Journal Article)
• Copyright: Copyright © 2016. Published by Elsevier Inc.

Chemical References

• Anti-Bacterial Agents
• Fluoroquinolones
• zabofloxacin

Topics

• Anti-Bacterial Agents (pharmacology)
• Ascites (microbiology)
• Blood (microbiology)
• Cerebrospinal Fluid (microbiology)
• Fluoroquinolones (pharmacokinetics, pharmacology)
• Humans
• Microbial Sensitivity Tests
• Pleural Effusion (microbiology)
• Pneumococcal Infections (microbiology)
• Streptococcus pneumoniae (drug effects, isolation & purification)