Meta-analysis of the incidence and risk of arterial and venous thromboembolic events associated with anti-EGFR agents in non-small-cell lung cancer patients.

Abstract

BACKGROUND:

To determine the risk of arterial and venous thromboembolic events (ATEs and VETs) associated with anti-epidermal growth factor receptor (EGFR) agents in non-small-cell lung cancer (NSCLC) patients.

METHODS:

Prospective randomized trials evaluating therapy with or without anti-EGFR agents in NSCLC patients. Data on VTEs and ATEs were extracted.

RESULTS:

A total of 8,410 patients from 12 trials were included for analysis. Anti-EGFR agents significantly increased the risk of all-grade and high-grade VTEs (Peto OR 1.50, 95%CI 1.16-1.95, P = 0.002; Peto OR 1.73, 95%CI: 1.32-2.26, p < 0.001, respectively), but not for all-grade and high-grade ATEs.

CONCLUSION:

The use of anti-EGFR agents significantly increased the risk of all-grade and high-grade VTEs but not for ATEs in NSCLC patients.

• Authors: Jian Zheng, Xiaoru Bai, Chengyu Hong, Hong Gao, Xiaoling Li
• Journal: Expert review of clinical pharmacology (Expert Rev Clin Pharmacol) Vol. 9 Issue 10 Pg. 1389-1395 (Oct 2016) ISSN: 1751-2441 [Electronic] England
• PMID: 27494194 (Publication Type: Journal Article)