Abstract |
We investigated the prognostic impact of the Ki-67 labeling index (LI) in minimally invasive follicular thyroid carcinoma ( FTC). We enrolled 192 patients (including four with distant metastasis at diagnosis) who were pathologically diagnosed as having minimally invasive FTC between 1998 and 2007 at Kuma Hospital. When the Ki-67 LI was higher than 5% in the hot area, we regarded it as a high Ki-67 LI. In a univariate analysis, patient age (≥45 years), high-frequent vascular invasion (≥4 in H&E specimens), and high Ki-67 LI significantly predicted the disease-free survival (DFS) of the patients. Since none of the patients <45 years old showed a recurrence, we performed a multivariate analysis of variables other than patient age. In the multivariate analysis including the presence of vascular invasion, high Ki-67 LI was an independent predictor of carcinoma recurrence. However, in the multivariate analysis including high-frequent vascular invasion, only high-frequent vascular invasion independently affected the DFS. These findings suggest that the Ki-67 LI has a rather strong prognostic value for the DFS of patients, although its impact was less than those of patient age and high-frequent vascular invasion.
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Authors | Yasuhiro Ito, Mitsuyoshi Hirokawa, Akira Miyauchi, Hiroo Masuoka, Tomonori Yabuta, Mitsuhiro Fukushima, Minoru Kihara, Takuya Higashiyama, Kaoru Kobayashi, Akihiro Miya |
Journal | Endocrine journal
(Endocr J)
Vol. 63
Issue 10
Pg. 913-917
(Oct 29 2016)
ISSN: 1348-4540 [Electronic] Japan |
PMID | 27432822
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adenocarcinoma, Follicular
(diagnosis, metabolism, pathology)
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Female
- Humans
- Ki-67 Antigen
(metabolism)
- Male
- Middle Aged
- Neoplasm Invasiveness
- Predictive Value of Tests
- Prognosis
- Staining and Labeling
(methods)
- Thyroid Neoplasms
(diagnosis, metabolism, pathology)
- Young Adult
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