Abstract | OBJECTIVES: METHODS: RESULTS:
Clozapine-induced hypersalivation was experienced by 92% of participants, with nocturnal hypersalivation more prevalent compared to daytime hypersalivation (85% versus 48%). Daytime drooling was severe in 18% of cases and was present on a frequent or constant basis for 20% of individuals. Hypersalivation had at least a moderate impact on the quality of life of 15% of study participants. CONCLUSIONS:
Clozapine-induced hypersalivation is the most prevalent adverse effect experienced by patients treated with clozapine and negatively impacts on quality of life, particularly if daytime drooling is present. The development of further strategies to ameliorate this adverse effect is required given the demonstrated lack of success to date in managing this condition.
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Authors | Senan Maher, Aoife Cunningham, Niamh O'Callaghan, Fintan Byrne, Colm Mc Donald, Shane McInerney, Brian Hallahan |
Journal | Therapeutic advances in psychopharmacology
(Ther Adv Psychopharmacol)
Vol. 6
Issue 3
Pg. 178-84
(Jun 2016)
ISSN: 2045-1253 [Print] England |
PMID | 27354906
(Publication Type: Journal Article)
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