Delphinidin prevents disuse muscle atrophy and reduces stress-related gene expression.

Abstract

Delphinidin is a member of the anthocyanidin class of plant pigments. We examined the effects of delphinidin on muscle atrophy. Oral administration of delphinidin suppressed the muscle weight loss induced by mechanical unloading. Microarray analysis showed that delphinidin suppresses the upregulation of oxidative stress-related gene expression, including the expression of Cbl-b. Thus, delphinidin may prevent unloading-mediated muscle atrophy.

• Authors: Motoki Murata, Reia Kosaka, Kana Kurihara, Shuya Yamashita, Hirofumi Tachibana
• Journal: Bioscience, biotechnology, and biochemistry (Biosci Biotechnol Biochem) Vol. 80 Issue 8 Pg. 1636-40 (Aug 2016) ISSN: 1347-6947 [Electronic] England
• PMID: 27180787 (Publication Type: Journal Article)

Chemical References

• Adaptor Proteins, Signal Transducing
• Anthocyanins
• Cblb protein, mouse
• Neuropeptides
• Rac1 protein, mouse
• Catalase
• Sod1 protein, mouse
• Superoxide Dismutase-1
• NADPH Oxidase 4
• NADPH Oxidases
• Nox4 protein, mouse
• Proto-Oncogene Proteins c-cbl
• rac1 GTP-Binding Protein
• delphinidin

Topics

• Adaptor Proteins, Signal Transducing (genetics, metabolism)
• Animals
• Anthocyanins (pharmacology)
• Body Weight (drug effects)
• Catalase (genetics, metabolism)
• Cell Line
• Gene Expression Profiling
• Gene Expression Regulation
• Hindlimb Suspension
• Male
• Mice
• Mice, Inbred C57BL
• Muscle, Skeletal (drug effects, metabolism)
• Muscular Atrophy (genetics, metabolism, physiopathology, prevention & control)
• Myoblasts (drug effects, metabolism)
• NADPH Oxidase 4
• NADPH Oxidases (genetics, metabolism)
• Neuropeptides (genetics, metabolism)
• Oxidative Stress (drug effects)
• Proto-Oncogene Proteins c-cbl (genetics, metabolism)
• Signal Transduction
• Superoxide Dismutase-1 (genetics, metabolism)
• rac1 GTP-Binding Protein (genetics, metabolism)