Abstract | BACKGROUND: METHODS: Women who had undergone oophorectomy between 1965 and 2011 were identified from the Swedish Patient Registry. Standard incidence ratios (SIRs) and 95 per cent confidence intervals for colorectal cancer risk were calculated compared with those in the general population. Stratification was carried out for unilateral and bilateral oophorectomy, and hysterectomy without specification of whether the ovaries were removed or not. Associations between the three oophorectomy options and colorectal cancer risk in different locations were assessed by means of hazard ratios (HRs) and 95 per cent confidence intervals calculated by Cox proportional hazards regression modelling. RESULTS: Of 195 973 women who had undergone oophorectomy, 3150 (1·6 per cent) were diagnosed with colorectal cancer at a later date (median follow-up 18 years). Colorectal cancer risk was increased after oophorectomy compared with that in the general population (SIR 1·30, 95 per cent c.i. 1·26 to 1·35). The risk was lower for younger age at oophorectomy (15-39 years: SIR 1·10, 0·97 to 1·23; 40-49 years: SIR 1·26, 1·19 to 1·33; P for trend < 0·001). The risk was highest 1-4 years after oophorectomy (SIR 1·66, 1·51 to 1·81; P < 0·001). In the multivariable analysis, women who underwent bilateral oophorectomy had a higher risk of rectal cancer than those who had only unilateral oophorectomy (HR 2·28, 95 per cent c.i. 1·33 to 3·91). CONCLUSION:
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Authors | J Segelman, L Lindström, J Frisell, Y Lu |
Journal | The British journal of surgery
(Br J Surg)
Vol. 103
Issue 7
Pg. 908-15
(Jun 2016)
ISSN: 1365-2168 [Electronic] England |
PMID | 27115862
(Publication Type: Journal Article)
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Copyright | © 2016 BJS Society Ltd Published by John Wiley & Sons Ltd. |
Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Cohort Studies
- Colorectal Neoplasms
(epidemiology)
- Female
- Follow-Up Studies
- Humans
- Middle Aged
- Multivariate Analysis
- Ovariectomy
- Proportional Hazards Models
- Registries
- Risk Assessment
- Sweden
(epidemiology)
- Young Adult
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