Hamamelitannin Analogues that Modulate Quorum Sensing as Potentiators of Antibiotics against Staphylococcus aureus.

Abstract

The modulation of bacterial communication to potentiate the effect of existing antimicrobial drugs is a promising alternative to the development of novel antibiotics. In the present study, we synthesized 58 analogues of hamamelitannin (HAM), a quorum sensing inhibitor and antimicrobial potentiator. These efforts resulted in the identification of an analogue that increases the susceptibility of Staphylococcus aureus towards antibiotics in vitro, in Caenorhabditis elegans, and in a mouse mammary gland infection model, without showing cytotoxicity.

• Authors: Arno Vermote, Gilles Brackman, Martijn D P Risseeuw, Bieke Vanhoutte, Paul Cos, Kristof Van Hecke, Koen Breyne, Evelyne Meyer, Tom Coenye, Serge Van Calenbergh
• Journal: Angewandte Chemie (International ed. in English) (Angew Chem Int Ed Engl) Vol. 55 Issue 22 Pg. 6551-5 (05 23 2016) ISSN: 1521-3773 [Electronic] Germany
• PMID: 27095479 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Anti-Bacterial Agents
• Hexoses
• Gallic Acid
• hamamelitannin

Topics

• Anti-Bacterial Agents (chemistry, pharmacology)
• Dose-Response Relationship, Drug
• Gallic Acid (analogs & derivatives, chemistry, pharmacology)
• Hexoses (chemistry, pharmacology)
• Microbial Sensitivity Tests
• Molecular Structure
• Quorum Sensing (drug effects)
• Staphylococcus aureus (drug effects)
• Structure-Activity Relationship