Association Between Thrombophilic Gene Mutations and the Risk of Vascular Access Thrombosis in Hemodialysis Patients.

Abstract

The cause of thrombosis in hemodialysis vascular access is considered to be of a multifactorial nature, including stenosis of the venous or arterial connection. Therefore, identification of relevant thrombotic risk factors could lead to an improved antithrombotic therapy. This case control study was performed to evaluate the relationship between Factor V (G1691A and A4070G) and Factor II polymorphisms and vascular access thrombosis in hemodialysis patients. One hundred and twenty-one patients undergoing dialysis were selected as subjects. This sample was divided into two groups; a case group of 60 patients who had sustained one or more thrombotic events that resulted in vascular access failure and a control group of 61 patients, who never had a thrombotic occlusion of a functioning permanent dialysis access. Our data demonstrated a significantly increased risk of vascular access thrombosis in carriers of the mutant FV (G1691A and A4070G) polymorphisms (P < 0.05).Further studies on a large-scale population and other genetic variants will be needed to find candidate genes for vascular access thrombosis in hemodialysis patients.

• Authors: Najiba Fekih-Mrissa, Aycha Sayeh, Anis Baffoun, Maher Beji, Meriem Mrad, Jalel Hmida, Brahim Nsiri
• Journal: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy (Ther Apher Dial) Vol. 20 Issue 2 Pg. 107-11 (Apr 2016) ISSN: 1744-9987 [Electronic] Australia
• PMID: 27004938 (Publication Type: Journal Article)
• Copyright: © 2016 International Society for Apheresis, Japanese Society for Apheresis, and Japanese Society for Dialysis Therapy.

Chemical References

• Factor V
• Prothrombin

Topics

• Adult
• Aged
• Case-Control Studies
• Factor V (genetics)
• Female
• Humans
• Male
• Middle Aged
• Mutation
• Polymorphism, Genetic
• Prothrombin (genetics)
• Renal Dialysis
• Risk Factors
• Thrombosis (etiology, genetics)
• Vascular Access Devices (adverse effects)