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Clinical Outcomes of Patients with Extensive Peritoneal Carcinomatosis Following Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy.

AbstractAIM:
The aims of this study were to explore clinical outcomes and assess the learning curve for cytoreductive surgery and perioperative intraperitoneal chemotherapy (PIC) for patients with a high peritoneal cancer index (PCI).
PATIENTS AND METHODS:
This was a retrospective study of patients with a PCI of 20 or more following CRS and PIC. Outcomes in five successive groups based on the operation date were analyzed.
RESULTS:
Three hundred and five patients were included in the study. The median overall survival (OS) was 89.3 months (95% confidence interval=58.9-107.6 months). OS at 1, 3 and 5 years of our study cohort was 89.4%, 70.4% and 57.5%, respectively. In terms of the learning curve, the mean duration of operation and hospital mortality decreased (p<0.001 and p=0.006 respectively). A trend for decreasing intensive care unit stay (p=0.497), high dependency unit stay (p=0.042) and total hospital stay (p=0.202) were also recorded.
CONCLUSION:
A high PCI alone should not be a contraindication for cytoreductive surgery and PIC in specialized centres.
AuthorsYeqian Huang, Nayef A Alzahrani, Terence C Chua, Ya Ruth Huo, David L Morris
JournalAnticancer research (Anticancer Res) Vol. 36 Issue 3 Pg. 1033-40 (Mar 2016) ISSN: 1791-7530 [Electronic] Greece
PMID26976995 (Publication Type: Journal Article)
CopyrightCopyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.
Topics
  • Adult
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
  • Colorectal Neoplasms (mortality, therapy)
  • Cytoreduction Surgical Procedures
  • Female
  • Hospital Mortality (trends)
  • Humans
  • Infusions, Parenteral
  • Length of Stay (trends)
  • Male
  • Middle Aged
  • Perioperative Care (methods)
  • Peritoneal Neoplasms (mortality, therapy)
  • Retrospective Studies
  • Survival Rate
  • Treatment Outcome

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