Abstract | AIM: The aims of this study were to explore clinical outcomes and assess the learning curve for cytoreductive surgery and perioperative intraperitoneal chemotherapy (PIC) for patients with a high peritoneal cancer index (PCI). PATIENTS AND METHODS: This was a retrospective study of patients with a PCI of 20 or more following CRS and PIC. Outcomes in five successive groups based on the operation date were analyzed. RESULTS: Three hundred and five patients were included in the study. The median overall survival (OS) was 89.3 months (95% confidence interval=58.9-107.6 months). OS at 1, 3 and 5 years of our study cohort was 89.4%, 70.4% and 57.5%, respectively. In terms of the learning curve, the mean duration of operation and hospital mortality decreased (p<0.001 and p=0.006 respectively). A trend for decreasing intensive care unit stay (p=0.497), high dependency unit stay (p=0.042) and total hospital stay (p=0.202) were also recorded. CONCLUSION:
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Authors | Yeqian Huang, Nayef A Alzahrani, Terence C Chua, Ya Ruth Huo, David L Morris |
Journal | Anticancer research
(Anticancer Res)
Vol. 36
Issue 3
Pg. 1033-40
(Mar 2016)
ISSN: 1791-7530 [Electronic] Greece |
PMID | 26976995
(Publication Type: Journal Article)
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Copyright | Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved. |
Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage, therapeutic use)
- Colorectal Neoplasms
(mortality, therapy)
- Cytoreduction Surgical Procedures
- Female
- Hospital Mortality
(trends)
- Humans
- Infusions, Parenteral
- Length of Stay
(trends)
- Male
- Middle Aged
- Perioperative Care
(methods)
- Peritoneal Neoplasms
(mortality, therapy)
- Retrospective Studies
- Survival Rate
- Treatment Outcome
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