Ixabepilone for the treatment of endometrial cancer.

Abstract

INTRODUCTION:

Endometrial cancer (EC) is the most common gynaecological cancer. Despite significant progress in the multimodality treatment approach, the prognosis remains poor for patients with advanced disease. Thus, there is the necessity of more effective strategies. The microtubule-stabilizing agent ixabepilone is the first drug in this new class of agents that has been approved for metastatic breast cancer treatment. Based on empiric data and on the clinical efficacy demonstrated in breast cancer, several clinical trials were proposed to define its role in EC. The aim of this review is to determine whether ixabepilone improved the clinical outcome in patients with locally advanced, recurrent or metastatic EC.

AREAS COVERED:

Preclinical and clinical studies of ixabepilone in endometrial cancer were analyzed and discussed. Data were obtained by searching for English peer-reviewed articles on PubMed, phase I and II studies registered on clincaltrials.gov, and related abstracts recently presented at major international congresses.

EXPERT OPINION:

Advanced or recurrent EC still represents a challenge and an unmet need in the panorama of gynaecological malignancies. Ixabepilone's future therapeutic role in EC remains ill defined. Nevertheless, despite its limited efficacy in EC, clinicians treating gynaecological tumours should be aware of its main aspects.

• Authors: Claudia Marchetti, Ilaria Piacenti, Ludovica Imperiale, Francesca De Felice, Serena Boccia, Violante Di Donato, Giorgia Perniola, Marco Monti, Innocenza Palaia, Ludovico Muzii, Pierluigi Benedetti Panici
• Journal: Expert opinion on investigational drugs (Expert Opin Investig Drugs) Vol. 25 Issue 5 Pg. 613-8 ( 2016) ISSN: 1744-7658 [Electronic] England
• PMID: 26949829 (Publication Type: Journal Article, Review)

Chemical References

• Antineoplastic Agents
• Epothilones
• ixabepilone

Topics

• Animals
• Antineoplastic Agents (adverse effects, pharmacokinetics, pharmacology, therapeutic use)
• Endometrial Neoplasms (drug therapy, metabolism)
• Epothilones (adverse effects, pharmacokinetics, pharmacology, therapeutic use)
• Female
• Humans