Comparison of Definitive Chemoradiotherapy in Locally Advanced Esophageal Squamous Cell Carcinoma.

Abstract

BACKGROUND:

This retrospective study was designed to estimate the efficacy and toxicity of definitive radiotherapy with concurrent or sequential docetaxel/S-1 for patients with locally advanced esophageal squamous cell carcinoma (ESCC).

METHODS:

Of the 62 eligible patients enrolled in this study during January 1, 2010 to December 31, 2014 from Qilu Hospital, Shandong University, Shandong Province, 39 patients received 3 cycles of docetaxel/S-1 during and after radiotherapy (concurrent chemoradiotherapy, CCRT), and 23 patients had radiotherapy followed by 3 cycles of docetaxel and S-1 (sequential chemoradiotherapy, SCRT).

RESULTS:

The CR of CCRT and SCRT groups were 48.72 and 21.74 %, respectively (p = 0.035). The median progress-free survival (PFS) of CCRT group (23.5 months) was significantly higher than SCRT group (11.7 months; p = 0.004). The median overall survival (OS) of CCRT group (33.5 months) also was significantly higher than SCRT group (24.0 months; p = 0.004). At 2 years, in this patient population, the rate of PFS of CCRT group was (44.2 ± 8.2 %), significantly higher than SCRT group (11.9 ± 9.6 %; p = 0.002). The 2-year OS rate of CCRT (68.6 ± 7.5 %) was significantly higher than SCRT group as well (42.0 ± 14.0 %; p = 0.002). The incidence of adverse events was higher in CCRT than SCRT group. No grade 4 or grade 5 adverse events occurred in our study.

CONCLUSIONS:

Definitive radiotherapy with concurrent or sequential docetaxel and S-1 for inoperable locally advanced ESCC was very well tolerated and remarkably active. In both CCRT and SCRT groups, acute toxicities were manageable. This regimen holds promises for treatment of esophageal carcinoma and warrants further investigation.

• Authors: Bin Yao, Bingxu Tan, Cong Wang, Qingxu Song, Jianbo Wang, Shanghai Guan, Yibin Jia, Yanan Ma, Xiaochen Huang, Yi Sun, Yufeng Cheng
• Journal: Annals of surgical oncology (Ann Surg Oncol) Vol. 23 Issue 7 Pg. 2367-72 (07 2016) ISSN: 1534-4681 [Electronic] United States
• PMID: 26932711 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Drug Combinations
• Taxoids
• S 1 (combination)
• Tegafur
• Docetaxel
• Oxonic Acid

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Carcinoma, Squamous Cell (pathology, therapy)
• Chemoradiotherapy
• Docetaxel
• Drug Combinations
• Esophageal Neoplasms (pathology, therapy)
• Female
• Follow-Up Studies
• Humans
• Male
• Oxonic Acid (administration & dosage)
• Prognosis
• Retrospective Studies
• Survival Rate
• Taxoids (administration & dosage)
• Tegafur (administration & dosage)