Abstract | INTRODUCTION: AIM: To assess and compare the salivary flow rates, relative uptake and ejection fractions in parotid and submandibular glands just before and one month after Iodine(131) therapy. MATERIALS AND METHODS: The study was conducted on 24 patients diagnosed with well differentiated thyroid carcinoma who underwent partial/total thyroidectomy and were due for radioactive iodine therapy. These patients were divided into two groups based on the lesion based dosimetry (Group A: 60-100Gy; Group B: 100-150Gy). Salivary gland assessment was done by salivary gland scintigraphy before and after RIT. STATISTICAL ANALYSIS: The data collected was tabulated and statistically analysed using SPSS software version16 using paired t-test and individual sample t-test. RESULTS: A statistically significant difference in the uptake percent and ejection fraction percent in the parotid and submandibular glands before RIT and one month after RIT was observed in the study. CONCLUSION: We inferred from the study that there was an overall decrease in uptake percent and ejection fraction percent one month post RIT in both parotid and submandibular glands. Also, a statistically significant difference was noted in the uptake and ejection fraction percent between Group A and Group B concluding the fact that the damage is dose related.
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Authors | Raj Kumar Badam, Jyotsna Suram, Dara Balaji Gandhi Babu, Shefali Waghray, Rahul Marshal, Sharath Chandra Bontha, Reddy Lavanya, Sudheer Kanth |
Journal | Journal of clinical and diagnostic research : JCDR
(J Clin Diagn Res)
Vol. 10
Issue 1
Pg. ZC60-2
(Jan 2016)
ISSN: 2249-782X [Print] India |
PMID | 26894178
(Publication Type: Journal Article)
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