In vivo evaluation of a simvastatin-loaded nanostructured lipid carrier for bone tissue regeneration.

Abstract

Alveolar bone loss has long been a challenge in clinical dental implant therapy. Simvastatin (SV) has been demonstrated to exert excellent anabolic effects on bone. However, the successful use of SV to increase bone formation in vivo largely depends on the local concentration of SV at the site of action, and there have been continuing efforts to develop an appropriate delivery system. Specifically, nanostructured lipid carrier (NLC) systems have become a popular type of encapsulation carrier system. Therefore, SV-loaded NLCs (SNs) (179.4 nm in diameter) were fabricated in this study, and the osteogenic effect of the SNs was evaluated in a critical-sized rabbit calvarial defect. Our results revealed that the SNs significantly enhanced bone formation in vivo, as evaluated by hematoxylin and eosin (HE) staining, immunohistochemistry, and a fluorescence analysis. Thus, this novel nanostructured carrier system could be a potential encapsulation carrier system for SV in bone regeneration applications.

• Authors: Xinxin Yue, Mao Niu, Te Zhang, Cheng Wang, Zhonglei Wang, Wangxi Wu, Qi Zhang, Chunhua Lai, Lei Zhou
• Journal: Nanotechnology (Nanotechnology) Vol. 27 Issue 11 Pg. 115708 (Mar 18 2016) ISSN: 1361-6528 [Electronic] England
• PMID: 26881419 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Lipids
• Simvastatin

Topics

• Animals
• Bone Diseases (pathology, therapy)
• Bone Regeneration (drug effects)
• Disease Models, Animal
• Humans
• Lipids (chemistry)
• Materials Testing
• Nanostructures (chemistry, therapeutic use)
• Rabbits
• Simvastatin (administration & dosage, chemistry, pharmacology)
• Skull (injuries, pathology)