Abstract | PURPOSE: METHODS: The expression of EPO-R and TF was investigated in 24 invasive breast carcinoma specimens. Immunohistochemical (IHC) methodologies according to ABC technique and double-staining IHC procedure were employed utilizing antibodies against EPO-R and TF. RESULTS: Expression of EPO-R and TF was demonstrated in the tumor cells in all breast cancer specimens. No staining for EPO-R and TF was visualized in normal breast tissue. Double staining studies revealed co-expression of both EPO-R and TF in breast cancer cells and endothelial cells. CONCLUSIONS: EPO-R and TF expression and their coexpression in breast cancer cells suggest a possibility that EPO-R might be responsible for some adverse effects and reduced survival observed in ESAs-treated breast cancer patients with anemia, possibly due to the interaction with TF. Further experimental studies are warranted to determine the role of both EPO-R and TF in the treatment with ESAs of breast cancer patients with chemotherapy-induced anemia.
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Authors | Marek Z Wojtukiewicz, Dominika Hempel, Joanna Kruszewska, Lech Zimnoch, Walter Kisiel, Ewa Sierko |
Journal | Journal of B.U.ON. : official journal of the Balkan Union of Oncology
(J BUON)
2015 Nov-Dec
Vol. 20
Issue 6
Pg. 1426-31
ISSN: 1107-0625 [Print] Cyprus |
PMID | 26854437
(Publication Type: Journal Article)
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Chemical References |
- Receptors, Erythropoietin
- Thromboplastin
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Topics |
- Anemia
(drug therapy)
- Breast Neoplasms
(chemistry, mortality)
- Female
- Humans
- Immunohistochemistry
- Receptors, Erythropoietin
(analysis)
- Thromboembolism
(etiology)
- Thromboplastin
(analysis)
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