The Difference of Treatment Results between Botulinum Toxin A Split Injection Sites and Botulinum Toxin A Non-Split Injection Sites for Hemifacial Spasm.

Abstract

OBJECTIVE:

To compare hemifacial spasm treatment results between Botulinum toxin A split injection sites and Botulinum toxin A non-split injection sites.

MATERIAL AND METHOD:

Thirty-one hemifacial spasm patients were randomly assigned into the non-split injection sites group (injecting Botulinum toxin A to the zygomaticus major and risorius each) or split injection sites group with the same amount of Botulinum toxin A as the first method (injection Botulinum toxin A to the zygomaticus major and minor and risorius two injections each) The main outcomes are onset of improvement and effective duration of treatment.

RESULTS:

Fifteen patients were assigned to non-split injection sites group and 16 patients were assigned to split injection sites group. The median onset of improvement in non-split injection sites group and split injection sites group was 4.0 and 4.5 days, respectively (p = 0.984). The effective duration of treatment in the non-split injection sites group was 60.0 days and in the split injection sites group was 54.5 days (p = 0.582).

CONCLUSION:

The splitting of injection sites did not signicantly improve the efficacy of Botulinum toxin A in the treatment of hemifacial spasm.

• Authors: Anuwat Prutthipongsit, Nipat Aui-aree
• Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet (J Med Assoc Thai) Vol. 98 Issue 11 Pg. 1119-23 (Nov 2015) ISSN: 0125-2208 [Print] Thailand
• PMID: 26817183 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Botulinum Toxins, Type A

Topics

• Adult
• Aged
• Aged, 80 and over
• Botulinum Toxins, Type A (therapeutic use)
• Double-Blind Method
• Female
• Hemifacial Spasm (drug therapy)
• Humans
• Injections, Intramuscular
• Male
• Middle Aged
• Prospective Studies
• Thailand
• Treatment Outcome