Loteprednol Etabonate 0.5%/Tobramycin 0.3% Compared with Dexamethasone 0.1%/Tobramycin 0.3% for the Treatment of Blepharitis.

Abstract

PURPOSE:

To compare the efficacy of loteprednol etabonate 0.5%/tobramycin 0.3% (LE/T) and dexamethasone 0.1%/tobramycin 0.3% (DM/T) ophthalmic suspensions in reducing select signs of blepharitis.

METHODS:

Data were pooled from two studies (one from the USA; one from China) of adults (n = 627) with blepharokeratoconjunctivitis treated with LE/T or DM/T four times daily for 2 weeks (safety population). Efficacy analyses included 495 eyes (247 LE/T, 248 DM/T) with any baseline sign of blepharitis.

RESULTS:

At Day 15, the least squares mean change from baseline in composite blepharitis severity was similar between LE/T (-2.86) and DM/T (-2.99) (90% CI for mean treatment difference: -0.35, 0.11). Intraocular pressure (IOP) increases ≥10 mmHg over baseline were reported for 1 US patient (DM/T group) and 19 Chinese patients (6 LE/T; 13 DM/T).

CONCLUSIONS:

LE/T was similarly effective in reducing the signs of blepharitis compared with DM/T, but demonstrated a better safety profile with respect to changes in IOP.

• Authors: Timothy L Comstock, Heleen H DeCory
• Journal: Ocular immunology and inflammation (Ocul Immunol Inflamm) Vol. 25 Issue 2 Pg. 267-274 (Apr 2017) ISSN: 1744-5078 [Electronic] England
• PMID: 26788833 (Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Anti-Allergic Agents
• Anti-Bacterial Agents
• Glucocorticoids
• Ophthalmic Solutions
• Dexamethasone
• Tobramycin
• Loteprednol Etabonate

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Anti-Allergic Agents (therapeutic use)
• Anti-Bacterial Agents (therapeutic use)
• Asian People
• Blepharitis (diagnosis, drug therapy, physiopathology)
• Dexamethasone (therapeutic use)
• Double-Blind Method
• Drug Therapy, Combination
• Female
• Glucocorticoids (therapeutic use)
• Humans
• Loteprednol Etabonate (therapeutic use)
• Male
• Middle Aged
• Ophthalmic Solutions
• Tobramycin (therapeutic use)
• Treatment Outcome
• Visual Acuity (physiology)
• Young Adult