[The regulation of CTLA4-Ig in bone and cartilage destruction of rheumatoid arthritis].

Abstract

CTLA4-Ig is a regulator of co-stimulation and inhibits the activation of T cells through interfering with the interaction of CD80/86 on antigen-presenting cells with CD28. Recently CTLA4-Ig has shown additional effect beyond T cell inhibition, such as direct inhibition of differentiation of osteoclast, enhancement of osteogenesis. These effects may contribute to prevention of bone destruction in rheumatoid arthritis.

• Authors: Naoki Iwamoto, Atsushi Kawakami
• Journal: Clinical calcium (Clin Calcium) Vol. 25 Issue 12 Pg. 1817-23 (Dec 2015) ISSN: 0917-5857 [Print] Japan
• PMID: 26608857 (Publication Type: English Abstract, Journal Article)

Chemical References

• CTLA-4 Antigen
• Immunoglobulins

Topics

• Animals
• Arthritis, Rheumatoid (drug therapy, immunology, pathology)
• Bone Diseases (drug therapy, immunology, pathology)
• CTLA-4 Antigen (immunology)
• Cartilage Diseases (drug therapy, immunology, pathology)
• Cell Differentiation (drug effects)
• Humans
• Immunoglobulins (immunology)