Nasal irrigation with saline solution significantly improves oxygen saturation in infants with bronchiolitis.

Abstract

AIM:

Published guidelines do not recommend nasal irrigation in bronchiolitis, but it is common practice in Italy, despite a lack of data on its benefits or adverse effects. This single-blind, multicentre, randomised controlled trial compared nasal irrigation using either isotonic 0.9% sodium chloride or hypertonic 3% sodium chloride with simple supportive care in infants with bronchiolitis.

METHODS:

We randomly assigned 133 infants up one year of age, who were admitted to the emergency department with bronchiolitis and an oxygen saturation (SpO2) of between 88 and 94%, to the isotonic (n = 47), hypertonic (n = 44) or standard care (n = 42) groups. Variations in SpO2 and the wheeze, air exchange, respiratory rate, muscle use (WARM) respiratory distress score were recorded at zero, five, 15, 20 and 50 minutes.

RESULTS:

Five minutes after the intervention, the median SpO2 value (95%) in the isotonic group was higher than both the hypertonic (94%) and the standard care (93%) groups. The differences between the isotonic and standard treatment groups were statistically significant at each time point, while the hypertonic group only reached significantly higher values after 50 minutes. However, the WARM score did not improve.

CONCLUSION:

A single nasal irrigation with saline solution significantly improved oxygen saturation in infants with bronchiolitis.

• Authors: Silvana Schreiber, Luca Ronfani, Sergio Ghirardo, Federico Minen, Andrea Taddio, Mohamad Jaber, Elisa Rizzello, Egidio Barbi
• Journal: Acta paediatrica (Oslo, Norway : 1992) (Acta Paediatr) Vol. 105 Issue 3 Pg. 292-6 (Mar 2016) ISSN: 1651-2227 [Electronic] Norway
• PMID: 26607495 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)
• Copyright: ©2015 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

Chemical References

• Saline Solution, Hypertonic
• Oxygen

Topics

• Bronchiolitis (blood, therapy)
• Humans
• Infant
• Nasal Lavage
• Oxygen (blood)
• Saline Solution, Hypertonic (administration & dosage)