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Small Molecules Take A Big Step Against Clostridium difficile.

Abstract
Effective treatment of Clostridium difficile infections demands a shift away from antibiotics towards toxin-neutralizing agents. Work by Bender et al., using a drug that attenuates toxin action in vivo without affecting bacterial survival, demonstrates the exciting potential of small molecules as a new modality in the fight against C. difficile.
AuthorsGreg L Beilhartz, John Tam, Roman A Melnyk
JournalTrends in microbiology (Trends Microbiol) Vol. 23 Issue 12 Pg. 746-748 (Dec 2015) ISSN: 1878-4380 [Electronic] England
PMID26547239 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Comment)
CopyrightCopyright © 2015 Elsevier Ltd. All rights reserved.
Chemical References
  • Anti-Bacterial Agents
Topics
  • Animals
  • Anti-Bacterial Agents (therapeutic use)
  • Clostridioides difficile (isolation & purification)
  • Clostridium Infections (drug therapy)
  • Virulence (drug effects)

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