Abstract | BACKGROUND: METHODS: The incidence of pathological fractures in 915 patients with 2.195 osteolytic metastases in the thoracic and lumbar spine was evaluated retrospectively on the basis of computed tomography (CT) scans between January 2000 and January 2012 depending on prescription and wearing of patient-customized orthopedic corsets. RESULTS: In the corset group, 6.8 and 8.0 % in no-corset group showed pathological fractures prior to RT, no significant difference between groups was detected (p = 0.473). After 6 months, patients in the corset group showed pathological fractures in 8.6 % and in no-corset group in 9.3 % (p = 0.709). The univariate and bivariate analyses demonstrated no significant prognostic factor for incidence of pathological fractures in both groups. CONCLUSIONS: In this analysis, we could show for the first time in more than 900 patients, that abandoning a general corset supply in patients with spinal metastases does not significantly cause increased rates of pathological fractures. Importantly, the incidence of pathological fracture after RT was small.
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Authors | Harald Rief, Robert Förster, Stefan Rieken, Thomas Bruckner, Ingmar Schlampp, Tilman Bostel, Jürgen Debus |
Journal | BMC cancer
(BMC Cancer)
Vol. 15
Pg. 745
(Oct 20 2015)
ISSN: 1471-2407 [Electronic] England |
PMID | 26486754
(Publication Type: Journal Article)
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Topics |
- Aged
- Aged, 80 and over
- Combined Modality Therapy
- Female
- Follow-Up Studies
- Fractures, Spontaneous
(epidemiology, etiology, mortality)
- Humans
- Incidence
- Male
- Middle Aged
- Osteolysis
- Prognosis
- Retrospective Studies
- Spinal Neoplasms
(complications, radiotherapy, secondary)
- Treatment Outcome
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