Super enhanced permeability and retention (SUPR) effects in tumors following near infrared photoimmunotherapy.

Abstract

To date, the delivery of nano-sized therapeutic agents to cancers largely relies on enhanced permeability and retention (EPR) effects that are caused by the leaky nature of cancer vasculature. However, nano-sized agents delivered in this way have demonstrated limited success in oncology due to the relatively small magnitude of the EPR effect. For achieving superior delivery of nano-sized agents, super-enhanced permeability and retention (SUPR) effects are needed. Near infrared photo-immunotherapy (NIR-PIT) is a recently reported therapy that treats tumors with light therapy and subsequently causes an increase in nano-drug delivery up to 24-fold compared with untreated tumors in which only the EPR effect is present. SUPR effects could enhance delivery into tumor beds of a wide variety of nano-sized agents including particles, antibodies, and protein binding small molecular agents. Therefore, taking advantage of the SUPR effects after NIR-PIT may be a promising avenue to utilize a wide variety of nano-drugs in a highly effective manner.

• Authors: Hisataka Kobayashi, Peter L Choyke
• Journal: Nanoscale (Nanoscale) Vol. 8 Issue 25 Pg. 12504-9 (Jul 07 2016) ISSN: 2040-3372 [Electronic] England
• PMID: 26443992 (Publication Type: Journal Article, Review)

Chemical References

• Antineoplastic Agents

Topics

• Animals
• Antineoplastic Agents (administration & dosage)
• Humans
• Immunotherapy
• Mice
• Neoplasms (therapy)
• Permeability
• Phototherapy