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Androgen deprivation therapy (castration therapy) and pedophilia: What's new.

Abstract
Andrology is a constantly evolving discipline, embracing social problems like pedophilia and its pharmacological treatment. With regard to chemical castration, the andrologist may perform an important role as part of a team of specialists. At present, no knowledge is available regarding hormonal, chromosomal or genetic alterations involved in pedophilia. International legislation primarily aims to defend childhood, but does not provide for compulsory treatment. We reviewed international literature that, at present, only comprises a few reports on research concerning androgen deprivation. Most of these refer to the use of leuprolide acetate, rather than medroxyprogesterone and cyproterone acetate, which present a larger number of side effects. Current opinions on chemical castration for pedophilia are discordant. Some surveys confirm that therapy reduces sexual thoughts and fantasies, especially in recidivism. On the other hand, some authors report that chemical castration does not modify the pedophile's personality. In our opinion, once existing legislation has changed, andrologists could play a significant role in the selection of patients to receive androgen deprivation therapy, due in part to their knowledge about its action and side effects.
AuthorsMauro Silvani, Nicola Mondaini, Alessandro Zucchi
JournalArchivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica (Arch Ital Urol Androl) Vol. 87 Issue 3 Pg. 222-6 (Sep 30 2015) ISSN: 1124-3562 [Print] Italy
PMID26428645 (Publication Type: Journal Article, Review)
Chemical References
  • Androgen Antagonists
  • Cyproterone Acetate
  • Leuprolide
  • Medroxyprogesterone
Topics
  • Androgen Antagonists (therapeutic use)
  • Andrology
  • Castration (methods)
  • Cyproterone Acetate (therapeutic use)
  • Evidence-Based Medicine
  • Humans
  • Leuprolide (therapeutic use)
  • Libido (drug effects)
  • Male
  • Medroxyprogesterone (therapeutic use)
  • Patient Selection
  • Pedophilia (prevention & control)
  • Sexual Behavior (drug effects)
  • Treatment Outcome

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