Fatal tracheal aspergillosis during rituximab combined chemotherapy for diffuse large B-cell lymphoma that developed after lung transplantation.

Abstract

Invasive tracheal aspergillosis (ITA) is an infection that is unique to patients who have undergone lung transplantation (LT). Although the activity of this disease often appears on imaging, we encountered a case of ITA that became exacerbated, despite few computed tomography (CT) findings, during rituximab combined chemotherapy for diffuse large B-cell lymphoma. ITA developed during immunosuppressive therapy after LT. Because CT findings may show false-negative results, bronchoscopy is recommended for such cases.

• Authors: K Kawamoto, Y Shibasaki, S Sato, H Nemoto, J Takizawa, M Narita, M Tsuchida, H Sone, M Masuko
• Journal: Transplant infectious disease : an official journal of the Transplantation Society (Transpl Infect Dis) Vol. 17 Issue 6 Pg. 872-5 (Dec 2015) ISSN: 1399-3062 [Electronic] Denmark
• PMID: 26369902 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Antineoplastic Agents
• Immunosuppressive Agents
• Rituximab

Topics

• Adult
• Antineoplastic Agents (administration & dosage, adverse effects, therapeutic use)
• Aspergillosis (etiology, pathology)
• Fatal Outcome
• Humans
• Immunosuppressive Agents (administration & dosage, adverse effects, pharmacology)
• Lung Transplantation (adverse effects)
• Lymphoma, B-Cell (drug therapy)
• Male
• Rituximab (administration & dosage, adverse effects, pharmacology)
• Tracheal Diseases (microbiology, pathology)