Vitamin D Status in Different Stages of Disease Severity in Dogs with Chronic Valvular Heart Disease.

Abstract

BACKGROUND:

In humans with heart disease, vitamin D deficiency is associated with disease progression and a poor prognosis. A recent study showed that serum 25-hydroxyvitamin D [25(OH)D] concentration, the hallmark of vitamin D status, was lower in dogs with heart failure than in normal dogs, and a low concentration was associated with poor outcome in dogs with heart failure.

OBJECTIVES:

To elucidate the vitamin D status of dogs with chronic valvular heart disease (CVHD) at different stages of disease severity.

ANIMALS:

Forty-three client-owned dogs with CVHD.

METHODS:

In this cross-sectional study, dogs were divided into 3 groups (14 dogs in Stage B1, 17 dogs in Stage B2, and 12 dogs in Stage C/D) according to ACVIM guidelines. Dogs underwent clinical examination including echocardiography. Serum 25(OH)D concentrations were measured in each dog.

RESULTS:

Serum 25(OH)D concentration was significantly lower in Stage B2 (median, 33.2 nmol/L; range, 4.9-171.7 nmol/L) and C/D (13.1 nmol/L; 4.9-58.1 nmol/L) than in Stage B1 (52.5 nmol/L; 33.5-178.0 nmol/L) and was not significantly different between Stage B2 and Stage C/D. Among clinical variables, there were significant negative correlations between 25(OH)D concentration and both left atrial-to-aortic root ratio and left ventricular end-diastolic diameter normalized for body weight.

CONCLUSIONS AND CLINICAL IMPORTANCE:

These results indicate that vitamin D status is associated with the degree of cardiac remodeling, and the serum 25(OH)D concentration begins to decrease before the onset of heart failure in dogs with CVHD.

• Authors: T Osuga, K Nakamura, T Morita, S Y Lim, K Nisa, N Yokoyama, N Sasaki, K Morishita, H Ohta, M Takiguchi
• Journal: Journal of veterinary internal medicine (J Vet Intern Med) 2015 Nov-Dec Vol. 29 Issue 6 Pg. 1518-23 ISSN: 1939-1676 [Electronic] United States
• PMID: 26332427 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.

Chemical References

• Vitamin D
• 25-hydroxyvitamin D

Topics

• Animals
• Chronic Disease
• Dog Diseases (blood)
• Dogs
• Female
• Heart Valve Diseases (blood, veterinary)
• Male
• Vitamin D (analogs & derivatives, blood)