Abstract |
We have recently designed and synthesized several novel iminoquinone anticancer agents that have entered preclinical development for the treatment of human cancers. Herein we developed and validated a quantitative HPLC-MS/MS analytical method for one of the lead novel anticancer makaluvamine analog, TCBA-TPQ, and conducted a pharmacokinetic study in laboratory rats. Our results indicated that the HPLC-MS/MS method was precise, accurate, and specific. Using this method, we carried out in vitro and in vivo evaluations of the pharmacological properties of TCBA-TPQ and plasma pharmacokinetics in rats. Our results provide a basis for future preclinical and clinical development of this promising anticancer marine analog.
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Authors | Jun-Xian Yu, Sukesh Voruganti, Dan-Dan Li, Jiang-Jiang Qin, Subhasree Nag, Su Xu, Sadanandan E Velu, Wei Wang, Ruiwen Zhang |
Journal | Chinese journal of natural medicines
(Chin J Nat Med)
Vol. 13
Issue 7
Pg. 554-60
(Jul 2015)
ISSN: 1875-5364 [Electronic] China |
PMID | 26233847
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Validation Study)
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Copyright | Copyright © 2015 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved. |
Chemical References |
- 7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one
- Antineoplastic Agents
- Pyrroles
- Quinolones
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Topics |
- Animals
- Antineoplastic Agents
(blood, pharmacokinetics)
- Chromatography, High Pressure Liquid
(methods)
- Pyrroles
(blood, pharmacokinetics)
- Quinolones
(blood, pharmacokinetics)
- Rats, Sprague-Dawley
- Tandem Mass Spectrometry
(methods)
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