Towards host-directed therapies for tuberculosis.

Abstract

The treatment of tuberculosis is based on combinations of drugs that directly target Mycobacterium tuberculosis. A new global initiative is now focusing on a complementary approach of developing adjunct host-directed therapies.

• Authors: Alimuddin Zumla, Markus Maeurer, Host-Directed Therapies Network, Jeremiah Chakaya, Michael Hoelscher, Francine Ntoumi, Roxana Rustomjee, Cristina Vilaplana, Dorothy Yeboah-Manu, Voahangy Rasolof, Paula Munderi, Nalini Singh, Eleni Aklillu, Nesri Padayatchi, Eusebio Macete, Nathan Kapata, Modest Mulenga, Gibson Kibiki, Sayoki Mfinanga, Thomas Nyirenda, Leonard Maboko, Alberto Garcia-Basteiro, Niaina Rakotosamimanana, Matthew Bates, Peter Mwaba, Klaus Reither, Sebastien Gagneux, Sarah Edwards, Elirehema Mfinanga, Salim Abdulla, Pere-Joan Cardona, James B W Russell, Vanya Gant, Mahdad Noursadeghi, Paul Elkington, Maryline Bonnet, Clara Menendez, Tandakha N Dieye, Bassirou Diarra, Almoustapha Maiga, Abraham Aseffa, Shreemanta Parida, Christian Wejse, Eskild Petersen, Pontiano Kaleebu, Matt Oliver, Gill Craig, Tumena Corrah, Leopold Tientcheu, Martin Antonio, Martin Rao, Timothy D McHugh, Aziz Sheikh, Giuseppe Ippolito, Gita Ramjee, Stefan H E Kaufmann, Gavin Churchyard, Andrie Steyn, Martin Grobusch, Ian Sanne, Neil Martinson, Rajhmun Madansein, Robert J Wilkinson, Bongani Mayosi, Marco Schito, Robert S Wallis
• Journal: Nature reviews. Drug discovery (Nat Rev Drug Discov) Vol. 14 Issue 8 Pg. 511-2 (Aug 2015) ISSN: 1474-1784 [Electronic] England
• PMID: 26184493 (Publication Type: Journal Article)

Chemical References

• Antitubercular Agents

Topics

• Antitubercular Agents (administration & dosage, pharmacology, therapeutic use)
• Drug Design
• Drug Therapy, Combination
• Humans
• Molecular Targeted Therapy
• Mycobacterium tuberculosis (drug effects)
• Tuberculosis (drug therapy)