Abstract | OBJECTIVES: MATERIALS AND METHODS: Patients (n=40) with advanced NSCLC were enrolled to receive escalating doses of icotinib, which was administrated on Day 1 followed by 28-day continuous dosing starting from Day 4. Four dosing regimens, 100mg b.i.d., 150 mg b.i.d., 125 mg t.i.d., and 200mg b.i.d. were studied. Pharmacokinetics (PK), safety, and efficacy of icotinib were evaluated. RESULTS:
Icotinib was well tolerated in Chinese patients with refractory NSCLC. No toxicity with >3 grades were reported in more than 2 patients under any dose levels. One complete response (3%) and 9 partial responses (23%) were received. Total disease control rate could reach at 73% and median progress-free survival (range) was 154 (17-462) days. PK exposure of icotinib increased with increase of dose in NSCLC patients. Food was suggested to increase PK exposure by ∼30%. Mean t1/2β was within 5.31-8.07 h. No major metabolite (>10% plasma exposure of icotinib) was found in NSCLC patients. CONCLUSIONS:
Icotinib with up to 400 mg/day exhibited good tolerance and preliminary antitumor activity in Chinese NSCLC patients. Pharmacokinetics of icotinib and 5 major metabolites were fully investigated in NSCLC patients. Optimized biologic dose (OBD) was finally recommended to be 125 mg t.i.d. for the later clinical study.
|
Authors | Dongyang Liu, Li Zhang, Yiwen Wu, Ji Jiang, Fenlai Tan, Yingxiang Wang, Yong Liu, Pei Hu |
Journal | Lung cancer (Amsterdam, Netherlands)
(Lung Cancer)
Vol. 89
Issue 3
Pg. 262-7
(Sep 2015)
ISSN: 1872-8332 [Electronic] Ireland |
PMID | 26162563
(Publication Type: Clinical Trial, Phase I, Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2015 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Antineoplastic Agents
- Crown Ethers
- Quinazolines
- icotinib
|
Topics |
- Aged
- Aged, 80 and over
- Antineoplastic Agents
(pharmacology, therapeutic use)
- Carcinoma, Non-Small-Cell Lung
(drug therapy, pathology)
- Combined Modality Therapy
- Crown Ethers
(pharmacology, therapeutic use)
- Female
- Humans
- Lung Neoplasms
(drug therapy, pathology)
- Male
- Middle Aged
- Neoplasm Staging
- Quinazolines
(pharmacology, therapeutic use)
- Risk Factors
- Treatment Outcome
|