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High metabolic N-oxidation of voriconazole in a patient with refractory aspergillosis and CYP2C19*17/*17 genotype.

AuthorsYoussef Bennis, Sandra Bodeau, Régis Bouquié, Guillaume Deslandes, Céline Verstuyft, Bérangère Gruson, Michel Andréjak, Anne-Sophie Lemaire-Hurtel, Taieb Chouaki
JournalBritish journal of clinical pharmacology (Br J Clin Pharmacol) Vol. 80 Issue 4 Pg. 782-4 (Oct 2015) ISSN: 1365-2125 [Electronic] England
PMID26138512 (Publication Type: Case Reports, Letter)
Chemical References
  • Antifungal Agents
  • Cytochrome P-450 CYP2C19
  • Voriconazole
Topics
  • Adult
  • Antifungal Agents (blood, metabolism, pharmacokinetics)
  • Aspergillosis (drug therapy, genetics, metabolism)
  • Cytochrome P-450 CYP2C19 (genetics)
  • Female
  • Genotype
  • Homozygote
  • Humans
  • Oxidation-Reduction
  • Treatment Failure
  • Voriconazole (blood, metabolism, pharmacokinetics)

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