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Arginine addiction in AML.

Abstract
In this issue of Blood, Miraki-Moud et al demonstrate that the majority of acute myeloid leukemias (AMLs) have low expression of argininosuccinate synthetase-1 (ASS1), rendering AML cell lines and primary AML blasts dependent on exogenous arginine and sensitized to arginine deprivation.
AuthorsWilliam Plunkett
JournalBlood (Blood) Vol. 125 Issue 26 Pg. 3971-2 (Jun 25 2015) ISSN: 1528-0020 [Electronic] United States
PMID26113532 (Publication Type: Journal Article, Comment)
Chemical References
  • Antineoplastic Agents
  • Polyethylene Glycols
  • Hydrolases
Topics
  • Animals
  • Antineoplastic Agents (pharmacology)
  • Humans
  • Hydrolases (pharmacology)
  • Leukemia, Myeloid, Acute (metabolism)
  • Polyethylene Glycols (pharmacology)

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