Four new phenanthrenoid dimers from Juncus effusus L. with cytotoxic and anti-inflammatory activities.

Abstract

Four new phenanthrenoid dimers, effususins A-D (1-4), were isolated from an ethanolic extract of the medullae of Juncus effuses (Juncaceae). Their structures were elucidated by 1D and 2D NMR spectroscopic analysis and mass spectrometry. Compounds 1-4 was in vitro evaluated for their cytotoxic activities by CCK-8 assay against five human cancer cell lines (SHSY-5Y, SMMC-7721, HepG2, Hela, and MCF-7) and their inhibitory effects on NO production in lipopolysaccharide-activated murine macrophage RAW264.7 cells. Effususin B exhibited moderate to strong cytotoxic activities against the tested cancer cell lines and moderate anti-inflammatory activity.

• Authors: Wei Ma, Feng Liu, Yun-Yun Ding, Yue Zhang, Ning Li
• Journal: Fitoterapia (Fitoterapia) Vol. 105 Pg. 83-8 (Sep 2015) ISSN: 1873-6971 [Electronic] Netherlands
• PMID: 26072042 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier B.V. All rights reserved.

Chemical References

• Anti-Inflammatory Agents
• Antineoplastic Agents, Phytogenic
• Phenanthrenes
• Plant Extracts
• Nitric Oxide

Topics

• Animals
• Anti-Inflammatory Agents (chemistry, isolation & purification)
• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification)
• Cell Line, Tumor (drug effects)
• Humans
• Magnoliopsida (chemistry)
• Mice
• Molecular Structure
• Nitric Oxide (metabolism)
• Phenanthrenes (chemistry, isolation & purification)
• Plant Extracts (chemistry)
• RAW 264.7 Cells (drug effects)